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Updated: Sep 4, 2025

Optimization of Crystal Growth for Neutron Macromolecular Crystallography
Published on: March 13, 2021
Synchronization of Cocrystal Dissolution and Drug Precipitation to Sustain Drug Supersaturation
Tatiane Cogo Machado1, Oisín N Kavanagh2, Simone Gonçalves Cardoso1
1Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.
Abstract:
A graphical analysis of both drug and coformer concentrations contributed by dissolving cocrystals is presented in the context of a simplified cocrystal phase diagram. The conceptual basis and analysis identify parameters that control cocrystal dissolution-drug supersaturation-precipitation (DSP) behavior. The important effects of coformer concentration, cocrystal dose, and cocrystal solubility on drug supersaturation levels are demonstrated and quantified by the DSPindex. While the studies presented rely on high and nonstoichiometric coformer concentrations contributed by the dissolving cocrystals, the concepts and findings can answer the question of whether and how much coformer should be added to cocrystal dissolution media or formulations.
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