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Quantum Cascade Laser-Based Vibrational Circular Dichroism Augmented by a Balanced Detection Scheme.

Daniel R Hermann1, Georg Ramer1, Markus Kitzler-Zeiler2

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|July 14, 2022
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Summary

This study introduces a faster Vibrational Circular Dichroism (VCD) measurement setup. The new system uses an external cavity quantum cascade laser (EC-QCL) and balanced detection, significantly reducing measurement times for molecular configuration analysis.

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Area of Science:

  • Spectroscopy
  • Chiroptical techniques
  • Molecular spectroscopy

Background:

  • Vibrational Circular Dichroism (VCD) is crucial for determining molecular absolute configuration without chiral reagents.
  • VCD signals are typically weak, requiring long measurement times for adequate signal-to-noise ratios (SNRs).
  • Existing Fourier transform infrared (FT-IR) instruments have limitations in VCD measurement speed.

Purpose of the Study:

  • To present an improved setup for enhanced VCD measurements.
  • To reduce measurement times while maintaining high signal quality.
  • To enable faster analysis of molecular chirality.

Main Methods:

  • Utilized an external cavity quantum cascade laser (EC-QCL) as a high-power light source.
  • Implemented a balanced detection module with a custom optical path for VCD.
  • Employed a two-detector setup for enhanced laser noise stabilization.

Main Results:

  • Achieved competitive noise levels in VCD spectra within 5 minutes.
  • Demonstrated noise level improvements up to a factor of 4 compared to single-detector EC-QCL-VCD.
  • Reduced measurement times by at least a factor of 6 compared to commercial FT-IR instruments, with comparable noise levels.

Conclusions:

  • The improved EC-QCL-VCD setup significantly accelerates VCD measurements.
  • The system is applicable for both qualitative and quantitative VCD analyses.
  • The high temporal resolution opens possibilities for monitoring optically active processes in real-time.