Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Flow analysis for optimal configuration of hemoperfusion device.

V Chang, A Battistin, R Rodrigue

    The International Journal of Artificial Organs
    |March 1, 1987
    PubMed
    Summary

    Reversing the flow in a hemoperfusion device significantly improves performance. This configuration minimizes stagnant flow and channeling, enhancing the efficiency of the hemoperfusion (HP) system.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A comparison of clinical development pathways to advance tuberculosis regimen development.

    BMC infectious diseases·2022
    Same author

    Does conventional early life academic excellence predict later life scientific discovery? An assessment of the lives of great medical innovators.

    QJM : monthly journal of the Association of Physicians·2020
    Same author

    Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis.

    PloS one·2016
    Same author

    Propentdyopent: the scaffold of a heme metabolite as an electron reservoir in transition metal complexes.

    Chemical communications (Cambridge, England)·2016
    Same author

    Therapeutic implications of activation of the host gene (Dleu2) promoter for miR-15a/16-1 in chronic lymphocytic leukemia.

    Oncogene·2013
    Same author

    Controversies in the management of cervical spondylotic myelopathy.

    Journal of neurosurgical sciences·2013

    Area of Science:

    • Biomedical Engineering
    • Fluid Dynamics

    Background:

    • Hemoperfusion (HP) is a clinical treatment requiring efficient blood purification.
    • Standard HP devices may suffer from suboptimal flow dynamics, impacting treatment efficacy.

    Purpose of the Study:

    • To investigate the flow characteristics of a standard hemoperfusion device.
    • To evaluate the impact of an inverse flow configuration on hemoperfusion device performance.

    Main Methods:

    • A two-dimensional, scaled model of a hemoperfusion device was constructed using plexiglass.
    • Glass beads simulated activated charcoal spheres, and colored solution visualized flow patterns.
    • Flow dynamics were analyzed in both standard and inverse configurations.

    Main Results:

    • The standard configuration exhibited significant flow stagnation and channeling.
    • The inverse configuration, with flow entering the tapered end, substantially reduced stagnation and channeling.
    • Improved flow distribution was observed in the inverse configuration.

    Conclusions:

    • Reversing the flow direction in hemoperfusion devices can optimize fluid dynamics.
    • The inverse configuration offers a promising approach to enhance hemoperfusion efficiency by mitigating undesirable flow patterns.

    Related Experiment Videos