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Pediatric HIV Case Identification Across 22 PEPFAR-Supported Countries During the COVID-19 Pandemic, October
Insights
Pediatric HIV testing decreased during the COVID-19 pandemic, but mobile and index testing strategies proved effective in identifying children living with HIV (CLHIV). Continued data analysis is crucial for optimizing testing approaches and sustaining progress toward global HIV/AIDS targets.
Area of Science:
- Public Health
- Epidemiology
- Infectious Diseases
Background:
- An estimated 150,000 children (0-14 years) acquired HIV globally in 2020.
- Optimizing pediatric HIV testing is crucial for linking children living with HIV (CLHIV) to treatment and achieving global HIV/AIDS targets.
- The COVID-19 pandemic presented challenges to sustained HIV testing and diagnosis efforts.
Purpose of the Study:
- To assess changes in pediatric HIV testing and diagnosis in 22 U.S. President's Emergency Plan for AIDS Relief (PEPFAR)-supported countries.
- To evaluate the impact of the COVID-19 pandemic on HIV testing strategies for children aged 1-14 years.
- To identify effective strategies for pediatric HIV case identification during the pandemic.
Main Methods:
- Analysis of HIV testing data and diagnoses among children (1-14 years) from October 2019 to September 2020 (two quarters pre-pandemic, two quarters post-pandemic).
- Disaggregation of testing data by age group, testing strategy, and fiscal year quarter.
- Comparison of testing volumes and case identification rates across different strategies, including outpatient, mobile, and index testing.
Main Results:
- Overall HIV testing decreased significantly (40.1%) from Q2 to Q3 2020, with a partial recovery in Q4.
- HIV case identification among children also decreased (29.4%) from Q2 to Q3, with a slight increase in Q4.
- Despite declines, mobile testing increased by 38%, facility-based index testing by 8%, and malnutrition-related testing by 7%; these strategies, along with testing in school-aged children (5-14 years), remained vital.
Conclusions:
- The COVID-19 pandemic disrupted pediatric HIV testing and diagnosis, necessitating adaptive strategies.
- Mobile and index testing, alongside targeted approaches for malnourished children and school-aged populations, proved resilient and essential.
- Continued utilization of programmatic, surveillance, and financial data is recommended to optimize the mix of testing strategies and minimize disruptions in identifying CLHIV.
Abstract:
During 2020, an estimated 150,000 persons aged 0-14 years acquired HIV globally (1). Case identification is the first step to ensure children living with HIV are linked to life-saving treatment, achieve viral suppression, and live long, healthy lives. Successful interventions to optimize pediatric HIV testing during the COVID-19 pandemic are needed to sustain progress toward achieving Joint United Nations Programme on HIV/AIDS (UNAIDS) 95-95-95 targets.* Changes in HIV testing and diagnoses among persons aged 1-14 years (children) were assessed in 22 U.S. President's Emergency Plan for AIDS Relief (PEPFAR)-supported countries during October 1, 2019-September 30, 2020. This period corresponds to the two fiscal quarters before the COVID-19 pandemic (i.e., Q1 and Q2) and the two quarters after the pandemic began (i.e., Q3 and Q4). Testing was disaggregated by age group, testing strategy, and fiscal year quarter. During October 2019-September 2020, PEPFAR supported 4,312,343 HIV tests and identified 74,658 children living with HIV (CLHIV). The number of HIV tests performed was similar during Q1 and Q2, decreased 40.1% from Q2 to Q3, and increased 19.7% from Q3 to Q4. The number of HIV cases identified among children aged 1-14 years (cases identified) increased 7.4% from Q1 to Q2, decreased 29.4% from Q2 to Q3, and increased 3.3% from Q3 to Q4. Although testing in outpatient departments decreased 21% from Q1 to Q4, testing from other strategies increased during the same period, including mobile testing by 38%, facility-based index testing (offering an HIV test to partners and biological children of persons living with HIV) by 8%, and testing children with signs or symptoms of malnutrition within health facilities by 7%. In addition, most tests (61.3%) and cases identified (60.9%) were among children aged 5-14 years (school-aged children), highlighting the need to continue offering HIV testing to older children. These findings provide important information on the most effective strategies for identifying CLHIV during the COVID-19 pandemic. HIV testing programs should continue to use programmatic, surveillance, and financial data at both national and subnational levels to determine the optimal mix of testing strategies to minimize disruptions in pediatric case identification during the COVID-19 pandemic.
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