Related Experiment Video
Updated: Sep 4, 2025

07:36
Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
Published on: May 16, 2020
5.4K
GITR Antibodies in Cancer: Not Ready for Prime Time
Tatiana Hernandez-Guerrero1, Victor Moreno1
1START Madrid-FJD, Hospital Fundación Jiménez Díaz, Madrid, Spain.
Abstract:
Glucocorticoid-induced TNF receptor (TNFR)-related protein (GITR) agonistic antibodies are expected to increase the antitumor response mainly by reducing the effect of Foxp3+ T-regulatory cells. TRX-518 is a novel GITR agonist that has shown good pharmacodynamic activity by depleting regulatory T cells (Tregs) in preclinical models, with limited clinical activity demonstrated in patients with advanced solid tumors. See related article by Davar et al., p. 3990.

