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Complex physiology and clinical implications of time-restricted eating
Max C Petersen1,2, Molly R Gallop3, Stephany Flores Ramos4
1Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.
Physiological Reviews
|July 14, 2022
Summary
Time-restricted eating (TRE) shows promise for metabolic health, but human study results vary. This review synthesizes research on TRE
Area of Science:
- Chrononutrition and metabolic health research.
- Investigating the impact of dietary timing on physiological functions.
Background:
- Time-restricted eating (TRE) involves daily food intake within a limited window.
- Rodent studies demonstrate TRE's therapeutic effects on body weight and metabolism.
- Human TRE studies show heterogeneous results due to varied regimens and populations.
Purpose of the Study:
- To review the history and physiology of eating and fasting.
- To discuss the interplay between circadian rhythms and TRE.
- To integrate preclinical and clinical findings on TRE's effects and identify research gaps.
Main Methods:
- Comprehensive literature review of preclinical and clinical studies on TRE.
- Analysis of TRE's impact on body weight and physiological functions.
- Summary of other time-related dietary interventions and future research directions.
Main Results:
- Rodent models show significant benefits of TRE on metabolic homeostasis.
- Human TRE studies present inconsistent outcomes, necessitating further investigation.
- Understanding the interaction between eating timing, circadian biology, and metabolism is crucial.
Conclusions:
- TRE is a promising dietary strategy with potential health benefits.
- More standardized human trials are needed to confirm TRE's efficacy and optimal protocols.
- Future research should focus on elucidating TRE's mechanisms and personalized application.
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