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Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Lipid Catabolism01:25

Lipid Catabolism

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Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
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Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

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Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
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Lipid Digestion01:06

Lipid Digestion

93.5K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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Related Experiment Video

Updated: Sep 4, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

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COVID-19 and Lipid Disorders.

Ulrich Julius1, Ulrike Schatz1, Sergey Tselmin1

  • 1Lipidology and Center for Extracorporeal Therapy, Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|July 14, 2022
PubMed
Summary

High cholesterol may increase SARS-CoV-2 susceptibility, while HDL-cholesterol is protective. COVID-19 alters lipid profiles, increasing cardiovascular and thromboembolic risks, necessitating continued lipid-lowering therapy.

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
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Related Experiment Videos

Last Updated: Sep 4, 2025

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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
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Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

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Area of Science:

  • Cardiovascular Science
  • Infectious Disease Epidemiology
  • Lipid Metabolism

Background:

  • Elevated cholesterol concentrations are linked to increased susceptibility to SARS-CoV-2 infection.
  • Cholesterol plays a critical role in the mechanisms of SARS-CoV-2 infection.
  • Higher high-density lipoprotein (HDL)-cholesterol levels appear to be protective against infection.

Purpose of the Study:

  • To investigate the role of cholesterol and other lipids in SARS-CoV-2 infection.
  • To examine the impact of COVID-19 on lipid profiles.
  • To assess the cardiovascular risks associated with COVID-19 and the role of lipid management.

Main Methods:

  • Analysis of lipid profiles (LDL-cholesterol, HDL-cholesterol, triglycerides, Lipoprotein(a)) in COVID-19 patients.
  • Review of existing literature on cholesterol's role in SARS-CoV-2 infection.
  • Assessment of cardiovascular disease incidence in COVID-19 patients.

Main Results:

  • COVID-19 is associated with decreased low-density lipoprotein (LDL)-cholesterol and HDL-cholesterol.
  • Triglycerides and Lipoprotein(a) levels were elevated during COVID-19.
  • COVID-19 patients face increased risks of cardiovascular diseases and thromboembolic events.

Conclusions:

  • Lipid alterations during COVID-19 contribute to increased cardiovascular and thromboembolic risks.
  • Lipoprotein(a) may drive atherosclerotic progression and thromboembolic events in COVID-19.
  • Continuation of lipid-lowering therapy, including lipoprotein apheresis, is recommended during COVID-19, pending further investigation.