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Gamma variant vertically transmitted from a mild symptomatic pregnant woman associated with fatal neonatal COVID

Walusa Assad Gonçalves-Ferri1, Cristina Galdonyi Carvalheiro1, Marisa Marcia Mussi-Pinhata1

  • 1Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto (FMRP), Departamento de Pediatria, Ribeirão Preto, SP, Brasil.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|July 14, 2022
PubMed

Herein we describe a mild symptomatic real-time reverse transcriptase- polymerase chain reaction-confirmed coronavirus 2 (SARS-CoV-2) infection in a pregnant woman who gave birth to a preterm infant, 32 weeks gestational age. The neonate was immediately isolated after delivery and developed severe respiratory disease that progressed to multisystem inflammatory syndrome and death on the seventh day of life. Genome sequencing detected the P.1 (gamma) variant in samples obtained at hospital admission (mother) and on the first (10h) and 13th days of life (neonate). Complete homology (mother's and newborn's sequences) confirmed vertical transmission. To our knowledge, this is the first report of vertically-transmitted SARS-CoV-2 P.1 (gamma) variant in a mild symptomatic infection in pregnancy associated with fatal COVID in a neonate.

Keywords:
Covid 19Preterm infantSars-CoV-2 variantVertical transmission

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