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Updated: Sep 4, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Exploring the epidemiology of disseminated intravascular coagulation: protocol for the DANish Disseminated

Simon Flæng1, Søren Nygaard2, Asger Granfeldt3

  • 1Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark siflae@clin.au.dk.

BMJ Open
|July 14, 2022
PubMed

Insights

The DANish Disseminated Intravascular Coagulation (DANDIC) Cohort Study will investigate the incidence, mortality, and treatment of disseminated intravascular coagulation (DIC). This research aims to identify prognostic factors for personalized patient care and improve clinical outcomes for this serious coagulation disorder.

Area of Science:

  • Clinical Medicine
  • Hematology
  • Epidemiology

Background:

  • Disseminated intravascular coagulation (DIC) is a critical coagulation disorder posing significant clinical challenges.
  • Existing knowledge gaps hinder effective patient management and treatment strategies for DIC.

Purpose of the Study:

  • To determine the incidence and mortality trends of DIC.
  • To identify prognostic factors for personalized prevention and treatment of DIC.
  • To describe current treatment patterns, safety, and effectiveness of DIC interventions.

Main Methods:

  • Establishment of the DANDIC Cohort using clinical data from the Central Denmark Region (1.3 million residents).
  • Study period: January 1, 2011, to July 1, 2021.
  • DIC case identification via laboratory biomarkers and expert adjudication, enriched with electronic medical chart data and linkage to national health registries.

Main Results:

  • The DANDIC Cohort will provide comprehensive data on DIC patient characteristics, treatments, and outcomes.
  • Longitudinal data will enable analysis of time trends and prognostic factor identification.
  • Integration with national registries ensures robust, long-term follow-up for epidemiological analysis.

Conclusions:

  • The DANDIC Cohort is a robust platform for advancing the understanding of DIC.
  • Findings will inform evidence-based guidelines for DIC prevention and treatment.
  • This study will contribute significantly to improving patient care for disseminated intravascular coagulation.
Abstract

Keywords:
Adult intensive & critical careBiochemistryBleeding disorders & coagulopathiesEPIDEMIOLOGYVASCULAR MEDICINE

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