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m6A Methylation in Cardiovascular Diseases: From Mechanisms to Therapeutic Potential

Longbo Li1, Nannan Xu1, Jia Liu1

  • 1Department of Cardiology, Second Hospital of Jilin University, Changchun, China.

Frontiers in Genetics
|July 15, 2022
PubMed

Insights

n6-methyladenosine (m6A) modification is crucial in cardiovascular disease (CVD) pathophysiology. This RNA modification regulates key cellular processes and may offer new therapeutic targets for delaying CVD progression.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular disease (CVD) is a major global health burden.
  • n6-methyladenosine (m6A) modification is increasingly recognized for its role in cardiovascular health and disease.
  • m6A influences critical cellular processes involved in CVD pathogenesis.

Purpose of the Study:

  • To review recent advances in m6A modification research related to CVD.
  • To summarize the mechanisms by which m6A affects CVD development.
  • To explore the therapeutic potential of targeting m6A modification for CVD.

Main Methods:

  • Literature review of studies on m6A modification in cardiovascular disease.
  • Analysis of m6A's role in regulating cellular processes like differentiation, proliferation, inflammation, autophagy, and apoptosis.
  • Examination of m6A's post-transcriptional regulatory functions in RNA.

Main Results:

  • m6A methylation significantly impacts cardiovascular homeostasis and pathophysiology.
  • m6A modification regulates key cellular pathways implicated in CVD.
  • Evidence suggests m6A can delay CVD progression through RNA regulation.

Conclusions:

  • m6A modification is a critical regulator in the context of cardiovascular disease.
  • Understanding m6A mechanisms provides insights into CVD development.
  • Targeting m6A represents a promising therapeutic strategy for cardiovascular diseases.

Keywords:
cardiovascular diseasescardiovascular pathophysiologyepigeneticsm6Am6A demethylasem6A methyltransferase

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