Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

635
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
635
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

501
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
501
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

70
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
70
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

429
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
429
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

23
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
23
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

476
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
476

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paraquat Peril: A Retrospective Study from the Frontlines of a Quaternary Care Hospital in South India.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2026
Same author

Point-of-care, Point-of-concern? A Commentary on What Ails Point-of-care Ultrasound Education.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2026
Same author

Incidence and Risk Factors for Deep Venous Thrombosis and Its Impact on Outcome in Patients Admitted to Medical Critical Care.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2024
Same author

Association of antibiotic duration and all-cause mortality in a prospective study of patients with ventilator-associated pneumonia in a tertiary-level critical care unit in Southern India.

BMJ open·2024
Same author

Competencies for Point-of-care Ultrasonography in ICU: An ISCCM Expert Panel Practice Recommendation.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2023
Same author

ISCCM Guidelines for Hemodynamic Monitoring in the Critically Ill.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2023

Related Experiment Video

Updated: Sep 4, 2025

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:37

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

420

Vasopressors in Septic Shock: The Quest for Refinement.

Kishore Pichamuthu1

  • 1Medical Intensive Care Unit, Christian Medical College Hospital, Vellore, Tamil Nadu, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|July 15, 2022
PubMed
Summary

This article discusses vasopressors for septic shock, highlighting the ongoing search for improved treatment strategies. It emphasizes the need for refined approaches to optimize patient outcomes in critical care settings.

Keywords:
EpinephrineHypotensionNorepinephrineSeptic shockTerlipressinVasopressinVasopressors

More Related Videos

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.1K
Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.4K

Related Experiment Videos

Last Updated: Sep 4, 2025

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:37

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

420
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.1K
Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.4K

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Intensive Care

Background:

  • Septic shock management remains complex, with vasopressors being a cornerstone therapy.
  • Current vasopressor strategies in septic shock require continuous evaluation and refinement.
  • Understanding the nuances of vasopressor use is crucial for improving patient survival.

Discussion:

  • The article explores the evolving role of vasopressors in septic shock.
  • It addresses the challenges and limitations associated with current vasopressor protocols.
  • Emphasis is placed on the quest for more effective and targeted vasopressor therapies.

Key Insights:

  • Vasopressor therapy in septic shock is an area of active research and clinical debate.
  • Refinement of vasopressor selection and administration is essential for better patient outcomes.
  • Personalized approaches to vasopressor use may offer future therapeutic advantages.

Outlook:

  • Future research should focus on identifying novel vasopressor agents or combinations.
  • Predictive biomarkers could guide individualized vasopressor therapy in septic shock.
  • Continued investigation into vasopressor mechanisms will drive treatment advancements.