Related Experiment Video

Updated: Sep 4, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

9.8K

Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?

Jing Li1,2, Wei Hu2, Ji-Yuan Zhang2

  • 1Peking University 302 Clinical Medical School, Beijing, China.

Journal of Clinical and Translational Hepatology
|July 15, 2022
PubMed

Insights

Acute severe hepatitis of unknown origin in children is emerging globally, sometimes leading to acute liver failure and transplantation. This review covers the outbreak, diagnosis, causes, and management challenges of this concerning pediatric liver disease.

Area of Science:

  • Pediatric Hepatology
  • Infectious Disease Epidemiology
  • Public Health

Background:

  • Emerging global cases of acute severe hepatitis in children of unknown etiology.
  • Significant concern due to progression to acute liver failure and need for liver transplantation.
  • Increasing attention from the medical and scientific community.

Purpose of the Study:

  • To summarize the current understanding of the pediatric hepatitis outbreak.
  • To discuss diagnostic criteria, potential causes, and underlying mechanisms.
  • To analyze management challenges and emphasize clinical strategies.

Main Methods:

  • Literature review and synthesis of existing data.
  • Analysis of outbreak patterns and diagnostic approaches.
  • Discussion of etiological hypotheses and pathogenetic mechanisms.

Main Results:

  • Overview of the global outbreak characteristics and diagnostic criteria.
  • Exploration of various potential etiologies and their proposed mechanisms.
  • Identification of key challenges in patient management.

Conclusions:

  • Need for a comprehensive approach to diagnose and manage pediatric hepatitis of unknown origin.
  • Importance of continued research to elucidate the causative agents and mechanisms.
  • Emphasis on collaborative efforts to unmask the etiology and improve patient outcomes.

Keywords:
ChildrenDiagnosticHepatitisManagementMechanism

More Related Videos

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

3.7K
Isolation of Neonatal Extrahepatic Cholangiocytes07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.4K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
56
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
35
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
471
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
81
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
1.5K
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
40