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Updated: Sep 4, 2025
07:48
Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
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Therapeutic angiogenesis-based strategy for peripheral artery disease
Jingxuan Han1,2, Lailiu Luo1,2, Olivia Marcelina1,2
1The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Theranostics
|July 15, 2022
Summary
Peripheral artery disease (PAD) is a growing health challenge. Therapeutic angiogenesis offers a promising treatment strategy, but requires further development for widespread clinical use.
Area of Science:
- Vascular Biology and Medicine
- Regenerative Medicine
- Medical Therapeutics
Background:
- Peripheral artery disease (PAD) presents a significant societal challenge with increasing prevalence.
- Severe PAD leads to amputation, mortality, reduced quality of life, and socioeconomic burden.
- PAD is a major complication in diabetic patients, increasing critical limb ischemia risk and poor prognosis.
Purpose of the Study:
- To review the progress and challenges of therapeutic angiogenesis for treating PAD.
- To highlight the potential of gene-based, cell-based, protein-based, and small molecule drug-based strategies.
- To identify areas needing improvement for clinical application and cost-effectiveness.
Main Methods:
- Review of current literature on therapeutic angiogenesis for PAD.
- Analysis of various therapeutic approaches, including gene therapy, cell therapy, protein therapy, and small molecule drugs.
- Examination of progress in clinical trials and remaining obstacles.
Main Results:
- Therapeutic angiogenesis has been explored for over two decades as a PAD treatment option.
- Several therapeutic strategies have advanced to clinical trials.
- Despite progress, efficacy, cost, and global application remain areas for improvement.
Conclusions:
- Therapeutic angiogenesis holds promise for PAD treatment, particularly for patients ineligible for surgery.
- Further research and development are crucial to enhance efficacy and accessibility.
- Overcoming current limitations is necessary for successful clinical translation and widespread application.
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