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Risk of Drug-induced Movement Disorders with Newer Antipsychotic Agents
George T Kannarkat1,2, Stanley N Caroff3, James F Morley1,2
1Philadelphia Parkinson's Disease Research, Education and Clinical Center, Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, PA, USA.
Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|July 15, 2022
Summary
Novel antipsychotics and long-acting formulations show comparable or lower risks of drug-induced movement disorders (DIMD) compared to older drugs. Some new options like lumateperone may offer reduced DIMD risk for psychosis treatment.
Area of Science:
- Pharmacology
- Neuroscience
- Clinical Psychiatry
Background:
- Recent advancements in antipsychotic medications include novel mechanisms and long-acting formulations.
- A comparative analysis of these new agents regarding drug-induced movement disorders (DIMD) risk was lacking.
Purpose of the Study:
- To comparatively assess the risk of drug-induced movement disorders (DIMD) associated with novel antipsychotics and their formulations.
- To evaluate the safety profile of newer antipsychotic options against older medications.
Main Methods:
- A systematic literature search of Medline (January 2010-February 2022) was conducted.
- Included primary research and review articles in English using specific drug names and terms like "extrapyramidal" and "tardive".
Main Results:
- Data from 6 novel antipsychotics, 4 novel formulations, and 3 experimental agents were analyzed.
- Both short- and long-term findings indicated comparable or reduced DIMD risk with novel antipsychotics and recent long-acting formulations versus older drugs.
Conclusions:
- Novel antipsychotics, including lumateperone and pimavanserin, demonstrate potential for treating psychosis with a lower risk of DIMD.
- Long-acting paliperidone may offer reduced DIMD risk, while other long-acting injectable formulations show similar risks to oral forms. Emerging targets for non-dopamine blockade psychosis treatment are promising.
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