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Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System

Sweta Adhikary1, John T Williams1

  • 1Vollum Institute, Oregon Health & Science University, Portland, OR, United States.

Frontiers in Systems Neuroscience
|July 15, 2022
PubMed
Summary

Opioid tolerance develops from continuous mu opioid receptor (MOR) activation, causing cellular adaptations that reduce pain relief. Understanding these complex mechanisms is key to managing chronic pain effectively.

Keywords:
electrophysiologykinasesopioidtolerancewithdrawal

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