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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Engineering immune-responsive biomaterials for skin regeneration.

Pingli Wu1, Yangyang Liang1, Guoming Sun2

  • 1College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei Province, China.

Biomaterials Translational
|July 15, 2022
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Biomaterials can improve wound healing, but perfect skin regeneration is challenging. Modulating the host immune response with engineered biomaterials offers a promising strategy for enhanced skin repair and regeneration.

Keywords:
biomaterialsimmune cellsimmunoresponseskin regeneration

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Immunology

Background:

  • Significant advances in biomaterials and tissue engineering have improved wound healing.
  • Perfect skin regeneration remains a clinical challenge, often complicated by host immune responses to implanted biomaterials.
  • The immune system critically influences both wound healing processes and outcomes.

Purpose of the Study:

  • To review recent advancements in immunomodulating biomaterials for skin repair and regeneration.
  • To discuss strategies for tailoring biomaterial properties to modulate immune responses.
  • To highlight the importance of understanding and manipulating immune reactions for overcoming skin regeneration challenges.

Main Methods:

  • Review of recent scientific literature on immunomodulating biomaterials in skin regeneration.
  • Analysis of strategies for controlling immune responses through biomaterial design.
  • Discussion of chemical, physical, and biological property modifications of biomaterials.

Main Results:

  • Immunomodulation is a key approach for developing pro-regenerative scaffolds.
  • Tailoring biomaterial properties can effectively regulate host immune reactions.
  • Understanding immune roles is crucial for advancing skin repair.

Conclusions:

  • Immunomodulating biomaterials represent a promising frontier in regenerative medicine for skin.
  • Strategic manipulation of biomaterial properties can guide the immune system towards a regenerative phenotype.
  • Further research into immuno-engineering holds potential for achieving perfect skin regeneration.