Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COX-2 inhibition improves immune system homeostasis and decreases liver damage in septic rats.

The Journal of surgical research·2009
Same author

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2009
Same author

3D-SURFER: software for high-throughput protein surface comparison and analysis.

Bioinformatics (Oxford, England)·2009
Same author

Total arch replacement with stented elephant trunk technique: a proposed treatment for complicated Stanford type B aortic dissection.

Journal of cardiac surgery·2009
Same author

Top-emitting white organic light-emitting devices with a one-dimensional metallic-dielectric photonic crystal anode.

Optics letters·2009
Same author

[Detection of tick and tick-borne pathogen in some ports of Inner Mongolia].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2009

Related Experiment Video

Updated: Sep 4, 2025

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
08:04

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

14.5K

Cellular modulation by the mechanical cues from biomaterials for tissue engineering.

Qiang Wei1, Shenghao Wang1, Feng Han1

  • 1Department of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Biomaterials Translational
|July 15, 2022
PubMed
Summary

This review highlights how mechanical cues from the extracellular matrix (ECM) guide stem cell behavior for tissue regeneration. Developing biomaterials that mimic native ECM mechanics is key for effective regenerative therapies.

Keywords:
cell behaviourmechanical cuesmulti-modalstiffnessviscoelasticity

More Related Videos

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

3.5K
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

21.1K

Related Experiment Videos

Last Updated: Sep 4, 2025

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
08:04

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

14.5K
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

3.5K
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

21.1K

Area of Science:

  • Biomaterials Science
  • Stem Cell Biology
  • Tissue Engineering

Background:

  • The extracellular matrix (ECM) provides mechanical cues crucial for stem cell fate, development, and homeostasis.
  • Tissue engineering utilizes scaffolds to repair or regenerate damaged tissues, aiming to replicate native ECM properties.
  • Artificial ECM development is vital for guiding cell functions and promoting tissue regeneration.

Purpose of the Study:

  • To review the impact of various ECM mechanical cues (elasticity, viscoelasticity, topography, external stimuli) on cell behavior.
  • To discuss strategies for developing biomaterials with tailored mechanical properties for cellular modulation.
  • To explore the mechanisms through which biomaterial mechanics regulate cell function for tissue regeneration.

Main Methods:

  • Review of existing literature on ECM mechanical cues and their effects on stem cells.
  • Discussion of natural and synthetic biomaterial development for mechanical property control.
  • Analysis of mechanisms linking mechanical cues to cell function and tissue regeneration.

Main Results:

  • ECM mechanical cues significantly influence stem cell behavior and differentiation.
  • Biomaterials can be engineered to mimic native ECM mechanics, guiding cell functions.
  • Understanding the interplay between mechanical cues and other microenvironmental factors is critical.

Conclusions:

  • Mimicking native ECM mechanical properties in scaffolds is essential for successful tissue regeneration.
  • Multimodal mechanical modulation presents challenges but offers significant potential for regenerative medicine.
  • Further research is needed to fully elucidate the complex interactions governing cell responses to mechanical stimuli.