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Immunotherapy of sarcomas with modified T cells
Preethika Mahalingam1, Maximilian Julve2, Paul Huang3
1Sarcoma Unit, The Royal Marsden Hospital.
Current Opinion in Oncology
|July 15, 2022
Summary
Modified T-cell therapies show promise for sarcomas, with ongoing trials targeting specific antigens like NY-ESO-1. Challenges include HLA-restriction and tumor microenvironments, requiring further therapeutic advancements.
Area of Science:
- Oncology
- Immunotherapy
- Cellular Therapy
Background:
- Sarcomas are a diverse group of cancers.
- Modified T-cell therapy is an emerging treatment strategy for sarcomas.
Purpose of the Study:
- To review the development of modified T-cell therapies in sarcomas.
- To discuss current and planned clinical trials for these therapies.
Main Methods:
- Review of published and ongoing clinical trials.
- Evaluation of T-cell receptor (TCR) and chimeric antigen receptor (CAR) T-cell therapies targeting sarcoma antigens.
Main Results:
- Several phase II trials are evaluating TCRs targeting NY-ESO-1 and MAGE A4 in specific sarcoma subtypes.
- Response rates up to 60% observed with NY-ESO-1 directed T cells in synovial sarcoma.
- Identified challenges include HLA-restriction, tumor microenvironments, lymphodepletion, and toxicities.
Conclusions:
- Modified T-cell therapy is a promising area for sarcoma treatment.
- Further development of therapeutic tools is needed to enhance specificity, persistence, and safety.
- Overcoming challenges in T-cell function and tumor microenvironment manipulation is crucial for maximizing therapeutic potential.
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