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Updated: Sep 4, 2025

Purification and Analysis of Caenorhabditis elegans Extracellular Vesicles
Published on: March 31, 2020
Role of extracellular vesicles in intercellular communication during reproduction
Kasun Godakumara1,2, Keerthie Dissanayake1,2,3, Mohammad Mehedi Hasan1,2,4
1Department of Pathophysiology, Institute of Biomedicine and Translational Medicine, Faculty of Medicine, Tartu University, Tartu, Estonia.
Abstract:
The mammalian reproduction is a process of controlled cellular growth and development regulated by constant communication between the gametes, the subsequent embryo and the maternal system. Extracellular vesicles (EVs) are involved in these communications to a significant degree from the gamete production and maturation to fertilization, embryo development and implantation. They regulate the cellular physiology and the immune reaction to bring about a favourable environment for a successful pregnancy. Deciphering the mechanisms employed in EV-mediated embryo maternal communication could improve our knowledge in mammalian reproduction and increase the efficiency of animal breeding.
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