Recent Advances of Natural Polysaccharide-based Double-network Hydrogels for Tissue Repair

Natural polysaccharide hydrogels have been extensively explored for many years due to their outstanding biocompatibility and biodegradability, which are very promising candidates as artificial soft materials for biomedical applications. However, their inferior mechanical performances greatly limited their applications. Introduction of double-network (DN) structure has been well documented to be an efficient strategy for significant improvement of the mechanical property of hydrogels. Here, recent progress of natural polysaccharide-based DN hydrogels is reviewed from the perspective of fundamental concepts on both design rationale and preparation strategies to biomedical application in tissue repair. Retrospect of the DN-strengthened polysaccharide hydrogels can give a deep insight into the fundamental relationship of such bio-based hydrogels among structural design, mechanical properties and practical demands, thereby prompting their translation to clinical application prospects.