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Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Updated: Sep 4, 2025

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The authors reply

Yoonsuk Lee1,2, Yong Sung Cha1,2

  • 1Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Critical Care Medicine
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