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circ_0041732 Promotes Breast Cancer Progression
Guolin Ye1, Suqun He1, Ruilin Pan1
1Department of Breast Surgery, The First People's Hospital of Foshan, Chancheng District, Foshan, GuangDong, P.R. China.
Molecular Cancer Research : MCR
|July 15, 2022
Summary
Circular RNA circ_0041732 promotes breast cancer progression by activating the NFκB and Hedgehog pathways. This oncogenic circular RNA is upregulated by E2F4 and sponges miR-541-3p, impacting cell proliferation and apoptosis.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Breast cancer is a leading cause of cancer-related deaths globally.
- Circular RNAs (circRNAs) are increasingly recognized for their roles in various cancers.
- The specific function of circ_0041732 in breast cancer remains to be fully elucidated.
Purpose of the Study:
- To investigate the role of circ_0041732 in breast cancer progression.
- To elucidate the regulatory mechanism of circ_0041732 in breast cancer.
Main Methods:
- RNA and protein expression analysis.
- Functional assays (cell proliferation, cell cycle, apoptosis).
- Mechanism assays including in vivo experiments.
Main Results:
- Circ_0041732 was significantly upregulated in breast cancer tissues and cell lines.
- E2F4 transcriptionally modulated circ_0041732.
- Circ_0041732 accelerated cell proliferation, impeded G2-M arrest, and reduced apoptosis.
- Circ_0041732 sponged miR-541-3p, enhancing RelA and GLI4 expression, activating NFκB and Hedgehog pathways.
Conclusions:
- Circ_0041732 acts as an oncogene in breast cancer.
- E2F4-mediated upregulation of circ_0041732 promotes breast cancer progression.
- The circ_0041732/miR-541-3p axis influences key cancer pathways, offering potential therapeutic targets.
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