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Feedforward activation of PRKN/parkin

Rayan Fakih1, Véronique Sauvé1, Kalle Gehring1

  • 1Department of Biochemistry and Centre de recherche en biologie structurale, McGill University, Montreal, Quebec, Canada.

Autophagy
|July 15, 2022
PubMed
Summary

Parkinson disease is linked to mutations in PRKN and PINK1, which control mitochondrial clearance via mitophagy. A newly identified secondary activation mechanism of PRKN by PINK1 offers potential for new Parkinson disease therapeutics.

Keywords:
AutophagyParkinson diseasekinasemitochondrianeurodegenerative diseaseprotein phosphorylationubiquitin

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