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Updated: Sep 4, 2025
Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
Published on: April 15, 2016
Animal Models of Hepatocellular Carcinoma for Local-Regional Intraarterial Therapies
Vishnu M Chandra1, Luke R Wilkins1, David L Brautigan1
1From the Department of Radiology and Medical Imaging (V.M.C., L.R.W.) and Department of Microbiology, Immunology, and Cancer Biology (D.L.B.), University of Virginia Health Systems, 1215 Lee St, PO Box 800170, Charlottesville, VA 22908.
Abstract:
Animal models play a crucial role in developing and testing new therapies for hepatocellular carcinoma (HCC), providing preclinical evidence prior to exploring human safety and efficacy outcomes. The interventional radiologist must weigh the advantages and disadvantages of various animal models available when testing a new local-regional therapy. This review highlights the currently available animal models for testing local-regional therapies for HCC and details the importance of considering animal genetics, tumor biology, and molecular mechanisms when ultimately choosing an animal model. Keywords: Animal Studies, Interventional-Vascular, Molecular Imaging-Clinical Translation, Molecular Imaging-Cancer, Chemoembolization, Liver © RSNA, 2022.
