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Published on: August 11, 2018
T helper profile in pregnant women recovered from COVID-19
Eleonora Tartaglia1, Veronica Bordoni1, Alessandra Oliva1
1INMI L. Spallanzani - IRCCS, Via Portuense 292, 00149 Rome, Italy.
Abstract:
T helper (Th) cell subsets play distinct and important roles during pregnancy. This work was focused on investigating the Th and cytokine profile in pregnant women recovered from COVID-19. To this aim, the frequency of Th1, Th2, Th17 subsets and the level of associated cytokines were analysed in pregnant women recovered from COVID-19 and in matched non-pregnant women. Principal component analysis highlighted a significant impact of pregnancy on Th profile with an increase of ex-Th17 subset and a parallel decrease of Th1 population. These modulations may participate in both preserving the pregnancy and reducing the risk of severe infection.
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