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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
Clinical and imaging experience with COVID-19 in nonvaccinated children with cancer
Gerald G Behr1, Joseph P Raphael2, Anita P Price1
1Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY, United States of America.
Insights
Children with cancer and COVID-19 (coronavirus disease 2019) face higher risks, especially those with hematologic malignancies. Pulmonary imaging abnormalities may indicate a poorer prognosis in this vulnerable pediatric population.
Area of Science:
- Pediatric Oncology
- Infectious Diseases
- Medical Imaging
Background:
- Children generally experience milder COVID-19 (coronavirus disease 2019) than adults.
- Limited data exist on clinical outcomes and imaging findings for pediatric cancer patients co-infected with COVID-19.
- Understanding this intersection is crucial for managing high-risk pediatric patients.
Purpose of the Study:
- To describe the clinical outcomes and medical imaging findings in a cohort of children with both cancer and COVID-19.
- To compare outcomes between children with hematologic malignancies and those with solid tumors.
Main Methods:
- Retrospective review of medical imaging and clinical data.
- Cohort divided into two groups: hematologic malignancies and solid tumors.
- Analysis of complications, mortality, and imaging abnormalities.
Main Results:
- Children with hematologic malignancies had a higher risk of complications, including death, compared to those with solid tumors.
- Pulmonary imaging abnormalities were more frequent in children with hematologic malignancies.
- The presence of pulmonary imaging abnormalities correlated with unfavorable outcomes.
Conclusions:
- Pediatric cancer patients with COVID-19, particularly those with hematologic malignancies, are at elevated risk for severe complications.
- Pulmonary imaging findings in this cohort can serve as indicators of prognosis.
- Further research is warranted to optimize care for these vulnerable children.
Abstract:
Children with COVID-19 fare much better than adults but less is known about children with both COVID-19 and a cancer diagnosis in terms of clinical outcome and imaging. We describe our experience with a cohort of children with COVID-19 and cancer who have undergone medical imaging. We reviewed imaging and recorded clinical data and separated this group into two subgroups - hematologic and solid malignancies. Our observational data show that 1)children with hematologic malignancies may be at higher risk for complications, including death than, those with solid tumors, 2) that pulmonary imaging in the former group more often shows abnormalities and 3) that presence of pulmonary imaging abnormalities may portend an unfavorable outcome.
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