Related Experiment Video
Updated: Sep 4, 2025

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
Published on: October 17, 2015
Aβ peptides stabilize GPCRs in inactive form and trigger inverse agonism in Alzheimer's disease
Amit Chaudhary1, Ashutosh Mani1
1Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, 211004, India.
Abstract:
Several G-protein coupled receptors (GPCR) are upregulated in Alzheimer's Disease (AD), which ought to facilitate neurotransmission, and improve cognition. Yet, despite this upregulation, associated physiological effects are not observed in AD patients. This paradox solicits urgent attention to find a suitable justification for disturbed neurotransmission in AD. This article focuses on the role of Aβ granules and their possible interaction with GPCRs that modulate neurotransmission and AD progression.
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
GPCRs Regulate Adenylyl Cylase Activity
GPCR Desensitization
Alzheimer's Disease: Treatment
Activation and Inactivation of G Proteins
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

