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Analysis of the relationship between the amplitude of aortic wall motion and heart function
Hideki Tashiro1, Samon Koyanagi2, Akihiro Honda3
1Division of Cardiology, St. Mary's Hospital, 422 Tubuku-honmachi, Kurume, Japan. tashiro@st-mary-med.or.jp.
Insights
Amplitude of motion of the aortic wall (AMAW) may indicate cardiac and vessel health. This study found AMAW correlates with diastolic dysfunction and left atrial pressure, suggesting its potential as a diagnostic marker.
Area of Science:
- Cardiology
- Vascular Biology
- Diagnostic Imaging
Background:
- The posterior aortic wall and left atrium are anatomically linked.
- The amplitude of motion of the aortic wall (AMAW) may serve as a non-invasive indicator of cardiovascular function.
Purpose of the Study:
- To investigate the relationship between cardiac and vascular functions and AMAW.
- To determine if AMAW can reflect cardiac and vessel health in patients with cardiovascular conditions.
Main Methods:
- 184 patients with cardiovascular diseases or undergoing health examinations were enrolled.
- Echocardiography and brachial-ankle pulse-wave velocity (baPWV) were performed.
- Correlations between echocardiographic indices, ankle-brachial index, baPWV, and AMAW were analyzed.
Main Results:
- AMAW significantly correlated with heart rate, ejection fraction (EF), wall thickness, E/e' ratio, and baPWV.
- In patients with EF ≥ 60%, E/e' and mean baPWV correlated with AMAW.
- In patients with EF < 60%, E/e' significantly correlated with AMAW.
Conclusions:
- AMAW may indicate elevated left atrial pressure, as it correlates with E/e' across different EF groups.
- AMAW's correlation with baPWV in patients with EF ≥ 60% suggests a link between vascular stiffness and diastolic dysfunction.
- AMAW shows potential as a marker reflecting both cardiac and vascular functions.
Purpose:
Because the posterior wall of the aorta and left atrium are interlocked, the amplitude of motion of the aortic wall (AMAW) may reflect cardiac and vessel functions. This study examined the relationship between cardiac and vessel functions and AMAW.
Methods:
Patients with cardiovascular diseases or patients undergoing health examinations who visited a participating hospital and underwent echocardiography and brachial-ankle pulse-wave velocity (baPWV) examinations were registered. The correlations between echocardiographic indices, ankle-brachial index, and baPWV and AMAW on M-mode echocardiography were analyzed.
Results:
Overall, 184 patients were enrolled. Heart rate (r = - 0.1587), ejection fraction (EF; r = 0.3240), wall thickness (r = - 0.1598), peak early diastolic mitral annular velocity (E) to peak early diastolic mitral annular velocity ratio (e'; r = - 0.2463), and baPWV (r = - 0.1928) significantly correlated with AMAW. In the stratified multiple regression analysis, E/e' (standardized partial regression coefficients = - 0.1863) and mean baPWV (standardized partial regression coefficients = - 0.1917) in patients with an EF of ≥ 60% (n = 114) significantly correlated with AMAW. In patients with an EF of < 60% (n = 70), E/e' (standardized partial regression coefficients = - 0.2443) significantly correlated with AMAW.
Conclusion:
Because E/e' correlated with AMAW in patients with an EF of < 60% or ≥ 60%, AMAW might be an indicator of left atrial pressure elevation. Moreover, because AMAW correlated with baPWV in patients with an EF of ≥ 60%, changes in the restricted left atrial volume might influence diastolic dysfunction. AMAW may be related to cardiac and vessel functions.
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