Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

214
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
214
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

161
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
161
Computed Tomography01:10

Computed Tomography

5.9K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single dose of 5 Gy can damage erythrocytes and consequently induces lymphocyte depletion in spleen and circulating blood.

Frontiers in immunology·2026
Same author

Targeting astrocytic Dp71 attenuates BBB disruption after traumatic brain injury through WTAP-associated m<sup>6</sup>A regulation of MMP2.

Science advances·2026
Same author

Privacy-Preserving Virtual Contrast-enhanced MRI for Nasopharyngeal Carcinoma: A Multi-center Study.

International journal of radiation oncology, biology, physics·2026
Same author

Prophylactic Cranial Irradiation in MRI-Staged Limited-Stage Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Survival and Neurocognitive Outcomes.

Cancers·2026
Same author

FreeTune4D: Anatomy-Aware 4D-MRI Motion Reconstruction Benchmark and Free Fine-Tuning Framework.

IEEE journal of biomedical and health informatics·2026
Same author

Development and Validation of a Quantitative LC-MS/MS Method for Measuring CYP4V2 Enzyme Activity via 12-Hydroxylauric Acid in rAAV-hCYP4V2 Gene Therapy Products.

Molecules (Basel, Switzerland)·2026

Related Experiment Video

Updated: Sep 4, 2025

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

15.8K

Volumetric multiphase ventilation imaging based on four-dimensional computed tomography for functional lung avoidance

Yu-Hua Huang1, Ge Ren1, Haonan Xiao1

  • 1Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.

Medical Physics
|July 16, 2022
PubMed
Summary

This study introduces a novel dynamic ventilation imaging framework using four-dimensional CT (4DCT) to capture lung function throughout breathing. This method reveals ventilation spatiotemporal heterogeneities, improving functional lung avoidance radiotherapy (FLART).

Keywords:
4DCTdeformable image registrationfunctional imaginglung cancerventilation

More Related Videos

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
10:44

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

606
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

46.9K

Related Experiment Videos

Last Updated: Sep 4, 2025

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

15.8K
Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
10:44

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

606
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

46.9K

Area of Science:

  • Medical Imaging
  • Radiotherapy Physics
  • Pulmonary Mechanics

Background:

  • Current computed tomography (CT)-based lung ventilation imaging (CTVI) provides static, not dynamic, ventilation data.
  • Lack of temporal information in static CTVI limits understanding of lung function during respiration.
  • Accurate lung ventilation dynamics are crucial for optimizing functional lung avoidance radiotherapy (FLART).

Purpose of the Study:

  • To develop a four-dimensional CT (4DCT)-based multiphase dynamic ventilation imaging framework.
  • To recover the complete lung ventilation process throughout the breathing cycle.
  • To enhance functional lung avoidance radiotherapy (FLART) by incorporating dynamic ventilation data.

Main Methods:

  • Utilized 15 free-breathing thoracic 4DCT scans from lung or esophageal cancer patients.
  • Employed mask-free image registration to derive deformation vector fields between breathing phases.
  • Estimated voxel-wise local expansion ratios as a ventilation surrogate and generated dynamic ventilation images.

Main Results:

  • The framework successfully recovered the dynamic lung ventilation process, maintaining physiological meaning per phase.
  • Mean interphase Spearman correlations varied (0.23 ± 0.20 to 0.93 ± 0.04), decreasing near end-expiration.
  • Significant ventilation spatiotemporal heterogeneities were observed, with only 26.2% of lung voxels matching global lung expansion patterns.

Conclusions:

  • The developed method extracts phase-resolved, respiration-correlated information, unlike conventional CTVI.
  • It highlights generally existing ventilation spatiotemporal heterogeneities during respiration.
  • Further studies will explore its potential for understanding lung function, respiration mechanics, and improving FLART accuracy.