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Updated: Sep 4, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Recent developments in promiscuous enzymatic reactions for carbon-nitrogen bond formation
Hui Xia1, Jinsong Song1, Changfan Li1
1School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, NO 1, Wenyuan Road, Nanjing 210023, PR China.
Abstract:
Biocatalytic promiscuity is a new field of enzyme application in biochemistry, which has received much attention and has developed rapidly in recent years. The promiscuous biocatalysis has been promoted as a useful supplement to traditional strategy for the formation of C-heteroatom bonds. The generation of carbon-nitrogen (CN) bonds is an important issue in synthetic chemistry and is indispensable for the manufacturing of various pharmaceuticals and agrochemicals. Therefore, numerous efficient and reliable synthetic methods for the formation of CN bonds have been developed in recent years. Enzymatic CN bond forming reactions catalyzed by lipases, cytochrome P450 monooxygenases, glycosyltransferases, amine dehydrogenases, proteases, acylases, amylases and halohydrin dehalogenases are well established for synthetic purposes. This review introduces the recent progress in the construction of CN bonds using promiscuous enzymes.
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