Related Experiment Video
Updated: Sep 4, 2025
Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
Intercritical photophobia in the migrainous patient. Proposal for diagnostic criteria
F Ly-Yang1, V Gómez-Calleja1, P Pérez-García1
1Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Introduction:
Photophobia is a symptom of abnormal light intolerance without pain sensation that requires an anamnesis and an examination to diagnose an underlying etiology.
Basic Procedure:
This article focuses on 30 clinical cases with isolated intense photophobia and on the review of the literature.
Objective:
The purpose of this article is to establish diagnostic criteria for photophobia.
Results:
The etiology of photophobia appears to be at the level of the intrinsically photosensitive retinal ganglion cells known as melanopsin cells and at a neurochemical level mediated by calcitonin-related peptide and the pituitary activating peptide cyclase.
Conclusion:
The treatment of photophobia could consist of monoclonal antibodies against calcitonin-related peptide and/or pituitary activating peptide cyclase.
