Related Experiment Video
Updated: Sep 4, 2025
06:24
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
913
Luteinizing Hormone Suppression Profiles in Men Treated With Exogenous Testosterone
Eduardo P Miranda1, Elizabeth Schofield2, Kazuhito Matsushita1
1Sexual & Reproductive Medicine Program, Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
The Journal of Sexual Medicine
|July 16, 2022
Summary
Testosterone therapy (TTh) can suppress luteinizing hormone (LH) secretion. Intramuscular TTh, higher baseline LH, and estradiol levels predict LH suppression in men undergoing treatment.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Men's Health
Background:
- Testosterone therapy (TTh) can suppress luteinizing hormone (LH) secretion due to the hypothalamic-pituitary-gonadal axis feedback.
- Observed variability in LH suppression during TTh necessitates further investigation into its predictors.
Purpose of the Study:
- To define the relationship between TTh and LH levels.
- To identify predictors of LH suppression in men receiving TTh.
Main Methods:
- Retrospective analysis of a prospectively maintained database of patients with testosterone deficiency (TD) treated with TTh.
- Collected demographic, clinical data, and vascular risk factor (VRF) status.
- Measured serum total testosterone and LH levels before and after ≥3 months of TTh, defining LH suppression as <1.0 IU/ml.
Main Results:
- Analysis included 227 men (mean age 58±14 years).
- Intramuscular route (OR=2.44), baseline LH (OR=0.94), and estradiol (OR=1.05) were significant predictors of LH suppression in the final adjusted model.
- While 73% experienced at least one episode of suppressed LH (<1 IU/ml), only 22% maintained suppressed levels throughout treatment.
Conclusions:
- LH suppression profiles during TTh are variable.
- Predictors include the route of administration, baseline LH, and estradiol levels.
- Understanding these profiles may aid in TTh dose titration and minimizing testicular atrophy.
Related Concept Videos
01:26Testosterone: Functions and Regulation
984
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
984
01:23Infertility in Males
329
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
329
01:22Hormonal Regulation of the Menstrual Cycle
657
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
657
01:27Signs of Puberty
594
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
594
01:28Menopause
246
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
246
01:20Disorders of the Male Reproductive System
554
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
554