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Related Experiment Video

Updated: Sep 4, 2025

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

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Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions.

Elangbam Tomtheelnganbee¹, Puja Sah¹, R Sharma²

¹Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, 793 022, India.

|July 16, 2022

Summary

Aging involves biochemical changes influenced by environment and biology. Calorie restriction (CR) promotes longevity and healthspan by modulating nutrient sensors and mitochondrial function, impacting metabolism.

Keywords:

AMPK Ageing Dietary restriction Mitochondria Sirtuins mTOR

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Area of Science:

Biochemistry
Cellular Biology
Gerontology

Background:

Aging is a complex biological process involving biochemical alterations.
Nutrient sensors and mitochondrial physiology are crucial for maintaining cellular homeostasis and energy metabolism.
Dysregulation of these systems contributes to age-related metabolic diseases.

Purpose of the Study:

To review the interdependent relationship between mitochondrial physiology and nutrient sensors during aging.
To explore their role in regulating metabolism and promoting longevity.
To highlight the impact of calorie restriction (CR) on these pathways.

Main Methods:

Literature review focusing on aging, metabolism, nutrient sensing, and mitochondrial function.
Analysis of the effects of calorie restriction (CR) on cellular energy metabolism.
Synthesis of current understanding on the interplay between aging hallmarks and metabolic regulation.

Main Results:

Mitochondrial physiology and nutrient sensor networks are intricately linked and altered during aging.
These alterations lead to mitochondrial damage and age-related metabolic decline.
Calorie restriction (CR) effectively modulates these networks, eliciting hormesis and improving metabolic healthspan.

Conclusions:

The interplay between mitochondria and nutrient sensors is central to aging and metabolic health.
Calorie restriction (CR) represents a key intervention for promoting longevity and healthspan by optimizing these pathways.
Further research into these mechanisms can inform strategies for combating age-related diseases.