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Related Concept Videos

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Keloid therapy: A neoteric comparative study.

Fathia M Khattab1, Hagar Bessar1, Elsayed M Khater1

  • 1Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Journal of Cosmetic Dermatology
|July 17, 2022
PubMed
Summary

Combined therapy of intralesional bleomycin and cryotherapy offers a more effective treatment for keloids than either modality alone. This approach significantly reduces scar height and improves pliability with minimal adverse effects.

Keywords:
bleomycincryotherapyintralesionalkeloids

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Area of Science:

  • Dermatology
  • Regenerative Medicine
  • Wound Healing

Background:

  • Keloids are fibroproliferative disorders marked by excessive collagen deposition in the skin.
  • These scars result from inflammation, surgery, or trauma, impacting skin structure and appearance.

Purpose of the Study:

  • To compare the efficacy and side effects of intralesional cryotherapy versus intralesional bleomycin for keloid treatment.
  • To evaluate the effectiveness of a combined therapy approach for keloid management.

Main Methods:

  • An interventional, comparative clinical trial involving 60 patients with keloids.
  • Patients were divided into three groups: combined bleomycin and cryotherapy, bleomycin alone, and cryotherapy alone.
  • Scar evaluation used the Vancouver Scar Scale, assessing lesion height and pliability.

Main Results:

  • Combined therapy demonstrated a statistically significant decrease in lesion height and improved pliability.
  • Both bleomycin and cryotherapy groups showed decreased lesion height, though not always statistically significant.
  • The combined group exhibited the most significant reduction in scar volume and associated symptoms.

Conclusions:

  • Intralesional cryotherapy and intralesional bleomycin are effective keloid treatments.
  • Combined therapy is a superior technique, offering greater efficacy and a favorable side effect profile for keloid treatment.
  • This study validates combined therapy as an effective modality for reducing keloid size and improving patient outcomes.