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Updated: Sep 4, 2025

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

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Invited commentary: Total anomalous pulmonary venous connection remains a challenging pediatric disease

Chi Chi Do-Nguyen1, Amy L Throckmorton2, Randy M Stevens3

  • 1Department of Cardiac and Thoracic Surgery, University of Michigan Hospital, Ann Arbor, Michigan, USA.

Journal of Cardiac Surgery
|July 17, 2022
PubMed

Insights

Long-term surgical outcomes for total anomalous pulmonary venous connection (TAPVC) show an 87.2% survival rate. Infracardiac TAPVC, venous obstruction, and mechanical ventilation increase mortality risk in these patients.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease Surgery

Background:

  • Total anomalous pulmonary venous connection (TAPVC) is a complex congenital heart defect requiring surgical intervention.
  • Long-term outcomes data are crucial for understanding the impact of surgical strategies on patient survival.

Purpose of the Study:

  • To evaluate the long-term surgical outcomes and survival rates in a large cohort of patients with TAPVC.
  • To identify risk factors associated with increased mortality in patients undergoing TAPVC repair.

Main Methods:

  • Retrospective analysis of 414 patients with TAPVC who underwent surgery between January 2003 and June 2019.
  • Inclusion of patients across various age groups, including those with late surgical referrals.

Main Results:

  • Overall survival rate of 87.2% was achieved over the study period (2003-2019).
  • Increased mortality risk was significantly associated with infracardiac TAPVC, pulmonary venous obstruction, and the need for postoperative mechanical ventilation.

Conclusions:

  • The study provides valuable insights into the long-term surgical outcomes of TAPVC, highlighting areas for improved patient management.
  • Identifying specific risk factors can guide clinical teams in optimizing treatment paradigms and improving survival for TAPVC patients.

Keywords:
congenital heart diseasepulmonary venous obstructionsurgical outcomestotal anomalous pulmonary venous connection

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