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Related Experiment Video

Updated: Sep 4, 2025

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Were they inoperable? Really?

Manuel J Antunes¹

¹Clinic of Cardiothoracic Surgery, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Journal of Cardiac Surgery

|July 17, 2022

Summary

This summary is machine-generated.

The MitraClip device treats mitral regurgitation in high-risk patients, but up to a third may experience residual issues requiring further intervention. This commentary discusses reasons for MitraClip failure and reintervention strategies.

Keywords:

MitraClip mitral valve repair

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Published on: November 24, 2016

Area of Science:

Cardiovascular Medicine
Interventional Cardiology

Background:

The MitraClip technique is widely used for mitral regurgitation in patients unsuitable for surgery.
Off-label MitraClip use is common, leading to varied outcomes.
Procedure failure, resulting in moderate to severe mitral regurgitation, affects up to one-third of patients.

Purpose of the Study:

To analyze institutional experience with MitraClip reintervention in patients with residual or recurrent mitral regurgitation.
To comment on reasons for MitraClip failure and indications for reintervention.
To contribute to refining patient selection criteria and identifying predictors of MitraClip failure.

Main Methods:

Review of a series of 17 patients undergoing reintervention after MitraClip implantation.
Analysis of institutional experience with surgical correction of failed MitraClip procedures.
Commentary on existing literature and clinical experience regarding MitraClip outcomes.

Main Results:

A significant proportion of patients (up to one-third) experience residual or recurrent mitral regurgitation after MitraClip.
Surgical reintervention is utilized in some cases for failed MitraClip procedures.
The study highlights the need for careful patient selection and understanding of failure modes.

Conclusions:

MitraClip failure necessitates reintervention, sometimes surgically, in a challenging patient population.
Further research is needed to refine patient selection and predict MitraClip failure.
The concept of "operation for the inoperable" applies to reinterventions after initial MitraClip procedures.