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Exercise-derived peptide protects against pathological cardiac remodeling.
Anwen Yin1, Ruosen Yuan1, Qingqing Xiao1
1Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Ebiomedicine
|July 17, 2022
Summary
Exercise stimulates the release of CCDC80tide, a peptide that protects the heart from damage and failure by inhibiting the JAK2-STAT3 pathway. This discovery offers new therapeutic strategies for heart conditions.
Area of Science:
- Cardiovascular Biology
- Exercise Physiology
- Molecular Medicine
Background:
- Exercise training offers cardioprotection against pathological cardiac remodeling and heart failure.
- The precise mechanisms underlying exercise-induced cardioprotection remain largely unknown.
Purpose of the Study:
- To identify novel exerkines involved in exercise-afforded cardioprotection.
- To elucidate the role of CCDC80tide in mitigating cardiac remodeling and dysfunction.
Main Methods:
- Integrative multi-omics analysis of skeletal muscle in response to exercise.
- Examination of CCDC80tide in human subjects post-exercise.
- Assessment of CCDC80tide in mouse models of hypertensive cardiac remodeling and cellular injury.
- Transcriptomic analysis and immunoprecipitation assays to explore molecular mechanisms.
Main Results:
- Coiled-coil domain-containing protein 80 (CCDC80) and its C-terminal peptide (CCDC80tide) are secreted into circulation via extracellular vesicles following exercise.
- Cardiac CCDC80tide expression protects against angiotensin II-induced cardiac hypertrophy and fibrosis in mice.
- CCDC80tide inhibits the JAK2-STAT3 signaling pathway, reducing cardiomyocyte hypertrophy, inflammation, and fibrosis in vitro.
- CCDC80tide directly interacts with JAK2, inhibiting its kinase activity and subsequent STAT3 phosphorylation.
Conclusions:
- CCDC80tide is a novel exerkine mediating exercise-induced cardioprotection.
- Inhibition of the JAK2-STAT3 pathway by CCDC80tide is a key mechanism in preventing pathological cardiac remodeling.
- CCDC80tide holds significant therapeutic potential for treating heart failure.
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