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General method for the analysis of pharmaceutical dosage forms by high-performance liquid chromatography
Journal of Chromatography
|March 27, 1987
Summary
A new high-performance liquid chromatography method simplifies pharmaceutical analysis. This approach uses a C18 column and a specific solvent system for accurate drug quantification in various formulations.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Sciences
Background:
- Accurate analysis of pharmaceutical dosage forms is crucial for quality control.
- Existing methods may lack simplicity or routine applicability.
Purpose of the Study:
- To develop a reliable and simple method for routine pharmaceutical analysis.
- To establish standardized extraction procedures for diverse drug formulations.
Main Methods:
- High-performance liquid chromatography (HPLC) utilizing a C18 Bondapak reversed-phase column.
- A binary solvent system composed of acetonitrile and 0.05 M potassium dihydrogen phosphate.
- Development and application of standardized drug extraction protocols.
Main Results:
- A robust HPLC method for pharmaceutical analysis was successfully developed.
- Standardized extraction procedures were validated across a range of pharmaceutical formulations.
- The method demonstrated reliability and simplicity for routine applications.
Conclusions:
- The developed HPLC method offers a practical solution for the routine analysis of pharmaceutical dosage forms.
- Standardized extraction procedures enhance the applicability of the analytical method.
- This contributes to improved quality control in pharmaceutical manufacturing.