Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 13-year nationwide analysis of "the weekend effect" on outcomes of esophageal variceal bleed.

Translational gastroenterology and hepatology·2026
Same author

Gastric Mucormycosis in a Critically Ill Patient Who Survived Without Surgery: A Case Report.

Cureus·2025
Same author

A Case Report of Undiagnosed Chronic Constipation With Considerable Stool Burden.

Cureus·2025
Same author

A 13-Year Nationwide Analysis of Nocardia and Actinomyces Infection Outcomes in Liver Transplant Recipients.

Transplantation proceedings·2025
Same author

A 13-year nationwide analysis of outcomes of non-variceal upper gastrointestinal bleeding in post-bariatric surgery patients.

Translational gastroenterology and hepatology·2025
Same author

Outcomes of Coronary Artery Bypass Grafting (CABG) Patients With and Without a History of Liver Transplant.

Cureus·2025

Related Experiment Video

Updated: Sep 4, 2025

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.0K

Undifferentiated Hepatic Sarcoma: A Rare Case.

James R Pellegrini1, Jose R Russe-Russe1, Tate W Higgins1

  • 1Internal Medicine, Nassau University Medical Center, East Meadow, USA.

Cureus
|July 18, 2022
PubMed
Summary
This summary is machine-generated.

Primary hepatic undifferentiated pleomorphic sarcoma (UPS) is a rare liver cancer. Diagnosis requires excluding other origins and identifying mesenchymal markers, crucial for early detection and improved patient survival.

Keywords:
clinical case reportgastrointestinalgastrointestinal neoplasmshepatic sarcomaimmunohistochemicaloncoonco-surgeryoncological imagingprimary hepatic sarcomaundifferentiated sarcoma

More Related Videos

Laparoscopic S7 Hepatectomy with Positive Fluorescence Staining
07:43

Laparoscopic S7 Hepatectomy with Positive Fluorescence Staining

Published on: May 9, 2025

227
Three-dimensional Location Approach with Silk Thread Guided Laparoscopic Segmentectomy for Liver Tumor
06:39

Three-dimensional Location Approach with Silk Thread Guided Laparoscopic Segmentectomy for Liver Tumor

Published on: May 23, 2025

129

Related Experiment Videos

Last Updated: Sep 4, 2025

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.0K
Laparoscopic S7 Hepatectomy with Positive Fluorescence Staining
07:43

Laparoscopic S7 Hepatectomy with Positive Fluorescence Staining

Published on: May 9, 2025

227
Three-dimensional Location Approach with Silk Thread Guided Laparoscopic Segmentectomy for Liver Tumor
06:39

Three-dimensional Location Approach with Silk Thread Guided Laparoscopic Segmentectomy for Liver Tumor

Published on: May 23, 2025

129

Area of Science:

  • Oncology
  • Pathology

Background:

  • Primary hepatic undifferentiated pleomorphic sarcoma (UPS) is a rare liver malignancy.
  • It presents nonspecifically, often diagnosed by exclusion through immunohistochemistry (IHC).

Observation:

  • A case of a 56-year-old male with epigastric pain and multiple liver masses is presented.
  • CT scans revealed numerous hepatic lesions; biopsy confirmed undifferentiated/pleomorphic sarcoma.
  • Histomorphology showed a spindle cell neoplasm; IHC was positive for smooth muscle actin (SMA) and focally for h-caldesmon, but negative for desmin.

Findings:

  • The diagnosis of primary hepatic UPS was established based on exclusion and IHC findings.
  • The tumor showed spindle cell morphology with limited specific mesenchymal differentiation markers.

Implications:

  • Considers UPS in the differential diagnosis of undifferentiated liver lesions.
  • Highlights the importance of IHC in diagnosing rare hepatic sarcomas.
  • Emphasizes early identification for preventing metastasis and improving patient outcomes.