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Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
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Immune Cell-Derived Extracellular Vesicles in the Face of Pathogenic Infections

Somayeh Keshtkar1,2,3, Saeede Soleimanian4, Maryam Kaviani3

  • 1Autophagy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Frontiers in Immunology
|July 18, 2022
PubMed

Insights

Immune cell-derived extracellular vesicles (EVs) show potential as antimicrobial therapies against various infections. These EVs carry bioactive molecules that help fight pathogens, offering a promising new treatment avenue.

Area of Science:

  • Immunology
  • Cell Biology
  • Infectious Diseases

Background:

  • Extracellular Vesicles (EVs) are crucial for intercellular communication.
  • Microbial infections pose significant global health challenges, exacerbated by antimicrobial resistance.
  • Immune cells release EVs with potential antimicrobial properties.

Purpose of the Study:

  • To review recent literature on immune cell-derived EVs in combating viral, bacterial, fungal, and parasitic infections.
  • To explore the mechanisms by which EVs mediate antimicrobial effects.
  • To assess the therapeutic potential of immune cell-derived EVs.

Main Methods:

  • Literature review of studies on immune cell-derived EVs and microbial infections.
  • Analysis of specific cargos within EVs and their role in antimicrobial activity.
  • Examination of the intercellular communication pathways involving EVs.

Main Results:

  • Specific molecular cargos within EVs, including miRNAs, mRNAs, and proteins, are involved in fighting pathogenic infections.
  • EVs can exert direct antimicrobial effects or induce antimicrobial responses in neighboring cells.
  • Immune cell-derived EVs demonstrate broad-spectrum activity against diverse pathogens.

Conclusions:

  • Immune cell-derived EVs represent a promising therapeutic strategy for infectious diseases.
  • The cargo carried by EVs is key to their antimicrobial efficacy.
  • Further research and clinical assessments are necessary to fully realize the therapeutic potential of EVs.
Keywords:
anti-microbialextracellular vesiclesimmune cellmicrobial infectionpathogens

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