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Circulating dihydrotestosterone may not reflect peripheral formation.

V Toscano, R Horton

    The Journal of Clinical Investigation
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Peripheral dihydrotestosterone (DHT) production differs between sexes and is not fully reflected in blood measurements. Urine production rates offer a more comprehensive view, especially in women, highlighting non-testosterone precursors.

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    Area of Science:

    • Endocrinology
    • Metabolism
    • Steroid biochemistry

    Background:

    • Dihydrotestosterone (DHT) is a key androgen, and its peripheral production is crucial for various physiological processes.
    • Accurate assessment of DHT production is essential for understanding androgenic status and related disorders.
    • Previous studies have primarily focused on blood levels, potentially underestimating peripheral formation.

    Purpose of the Study:

    • To compare blood (PBDHT) and urine (PUDHT) production rates of DHT in normal men and women.
    • To investigate whether peripheral DHT formation is accurately reflected in blood measurements.
    • To explore sex differences in DHT and related steroid metabolism.

    Main Methods:

    • Measurement of blood and urine production rates of dihydrotestosterone (DHT).
    • Quantification of DHT and 3 alpha-androstanediol (3 alpha diol) excretion.
    • Analysis of 3 alpha-androstanediol glucuronide (3 alpha diolG) in plasma and urine.

    Main Results:

    • In men, PBDHT was similar when measured at both sites.
    • In women, PUDHT was significantly greater than PBDHT, indicating substantial peripheral DHT formation not captured by blood.
    • Excretion rates of DHT and 3 alpha diol were similar between sexes, despite differing blood levels, while 3 alpha diolG showed significant sex differences in both plasma and urine.

    Conclusions:

    • Peripheral formation of DHT and 3 alpha diol is not accurately determined by blood measurements alone.
    • The discrepancy between blood and urine production rates in women suggests a significant role for non-testosterone precursors in 5 alpha-reduced steroid synthesis.
    • Urinary 3 alpha diolG measurements may offer valuable insights into peripheral androgen metabolism and formation pathways.