Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia-related changes with megakaryoblastic
Daniele Avenoso1, Pramila Krishnamurthy1, Jonathan Salisbury2
1Department of Haematological Medicine King's College Hospital NHS Foundation Trust London UK.
Abstract:
Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic-related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv(3) and t(3;3). One of the peculiarities of this case is the positivity of CD34+ within the abnormal megakaryoblasts; CD61 immunohistochemistry highlights the heavily infiltration of bone marrow from abnormal megakaryoblasts.
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