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Related Concept Videos

Hypodermis01:02

Hypodermis

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Related Experiment Video

Updated: Sep 4, 2025

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
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Engineering Human Beige Adipose Tissue.

Maria A Gonzalez Porras1,2, Katerina Stojkova1, Francisca M Acosta3

  • 1Department of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, San Antonio, TX, United States.

Frontiers in Bioengineering and Biotechnology
|July 18, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a method to create functional beige adipose microtissues from human microvascular fragments (MVFs) for potential metabolic disease therapies and drug development.

Keywords:
beige adipocytehydrogelmicrotissuemicrovascular fragmentsobesity

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Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
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Area of Science:

  • Biotechnology and Regenerative Medicine
  • Adipose Tissue Engineering
  • Metabolic Disease Research

Background:

  • Beige adipose tissue plays a crucial role in thermogenesis and metabolic regulation.
  • Current methods for generating functional adipose tissues are limited, especially for therapeutic applications.
  • Human microvascular fragments (MVFs) offer a potential cell source for tissue engineering.

Purpose of the Study:

  • To describe a novel method for generating functional beige (thermogenic) adipose microtissues.
  • To utilize human microvascular fragments (MVFs) isolated from adult adipose tissue.
  • To explore the therapeutic potential of these engineered microtissues for metabolic diseases and drug development.

Main Methods:

  • Isolation of MVFs from adipose tissue of adults over 50 years of age.
  • Induction of MVFs to form functional beige adipose microtissues.
  • Characterization of microtissue thermogenic gene markers, lipid metabolism, and mitochondrial respiration.

Main Results:

  • Successfully generated functional beige adipose microtissues from human MVFs.
  • The engineered tissues expressed key thermogenic gene markers.
  • Demonstrated enhanced lipid metabolism and increased mitochondrial respiration, mimicking beige adipose tissue functions.

Conclusions:

  • MVFs provide a viable autologous cell source for creating functional beige adipose microtissues.
  • This approach enables rapid vascularization, crucial for post-transplantation success.
  • The method holds promise for autologous therapy of metabolic diseases and personalized drug development.