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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Gene polymorphisms in asthma: a narrative review.

Fei Shi1, Yu Zhang1, Chen Qiu2

  • 1Department of Emergency Medicine, Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, China.

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This review summarizes 10 gene variants linked to asthma risk over 20 years, aiding understanding of genetic factors in asthma development. Future personalized asthma therapy may rely on genotypic profiling.

Keywords:
Asthmagene polymorphismgenome-wide association studysingle nucleotide polymorphism

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Area of Science:

  • Genetics
  • Pulmonology
  • Epidemiology

Background:

  • Asthma is a complex disease influenced by genetic and environmental interactions.
  • Genome-wide association studies (GWAS) highlight the role of genetic variation in asthma.
  • Understanding genetic factors is key to unraveling asthma's etiology.

Purpose of the Study:

  • To systematically review literature on gene polymorphisms associated with asthma.
  • To elucidate the relationship between genetic factors and asthma susceptibility.
  • To consolidate knowledge on genetic variants impacting asthma risk.

Main Methods:

  • Literature search of PubMed and FMRS databases (2000-2021).
  • Keywords: "asthma" and "gene polymorphism".
  • Inclusion of English-language articles focusing on genetic factors in asthma.

Main Results:

  • Summarized information on 10 gene variants associated with asthma risk.
  • Identified numerous candidate genes implicated in asthma susceptibility.
  • Highlighted specific gene variations influencing asthma patient responses.

Conclusions:

  • Genetic variants play a significant role in asthma risk.
  • Personalized therapy based on genotypic profiling is a future direction.
  • Further research is needed to link gene polymorphisms to asthma's pathophysiological mechanisms.