Related Experiment Video
Updated: Sep 4, 2025
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
DDX5: an expectable treater for viral infection- a literature review
Minghui Hu1, Hongying Zheng1, Jingqi Wu2
1Clinical Lab, The Affiliated Hospital of Qingdao University, Qingdao China.
Background And Objective:
DEAD-box protein (DDX)5 plays important roles in multiple aspects of cellular processes that require modulating RNA structure. Alongside the canonical role of DDX5 in RNA metabolism, many reports have shown that DDX5 influences viral infection by directly interacting with viral proteins. However, the functional role of DDX5 in virus-associated cancers, as well as the identity of DDX5 in virus infection-associated signaling pathways, has remained largely unexplained. Here, we further explore the precise functions of DDX5 and its potential targets for antiviral treatment.
Methods:
We searched the PubMed and PMC databases to identify studies on role of DDXs, especially DDX5, during various viral infection published up to May 2022.
Key Content And Findings:
DDX5 functions as both a viral infection helper and inhibitor, which depends on virus type. DDXs proteins have been identified to play roles on multiple aspects covering RNA metabolism and function.
Conclusions:
DDX5 influences viral pathogenesis by participating in viral replication and multiple viral infection-related signaling pathways, it also plays a double-edge sword role under different viral infection conditions. Deep investigation into the mechanism of DDX5 modulating immune response in host cells revealed that it holds highly potential usage for future antiviral therapy. We reviewed current studies to provide a comprehensive update of the role of DDX5 in viral infection.
Insights
DEAD-box protein (DDX)5 has a dual role in viral infections, acting as both a helper and inhibitor depending on the virus. Understanding DDX5
Area of Science:
- Molecular Biology
- Virology
- Immunology
Background:
- DEAD-box protein (DDX)5 is crucial for RNA structure modulation in cellular processes.
- DDX5 interacts with viral proteins, influencing viral infections.
- The precise role of DDX5 in virus-associated cancers and signaling pathways is not fully understood.
Purpose of the Study:
- To explore the specific functions of DDX5 in viral infections.
- To identify potential antiviral treatment targets related to DDX5.
- To provide a comprehensive review of DDX5's role in viral pathogenesis.
Main Methods:
- Literature search of PubMed and PMC databases.
- Inclusion of studies on DEAD-box proteins (DDXs), particularly DDX5, in viral infections.
- Review of studies published up to May 2022.
Main Results:
- DDX5 exhibits context-dependent roles, acting as both a helper and inhibitor in viral infections.
- DDX5 influences viral replication and associated signaling pathways.
- DDX5 modulates host immune responses, presenting therapeutic potential.
Conclusions:
- DDX5 plays a complex, dual role in viral infections.
- Investigating DDX5 mechanisms offers promising avenues for antiviral therapies.
- Further research on DDX5 is essential for understanding viral pathogenesis and developing treatments.
More Related Videos
06:02Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
08:52Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Related Concept Videos
01:29Subviral Agents
02:33Retroviruses