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Anthralin stability in various vehicles.

P G Green, C T Kennedy, D R Forbes

    Journal of the American Academy of Dermatology
    |May 1, 1987
    PubMed
    Summary
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    Anthralin stability varies by formulation and concentration. Weaker anthralin preparations are less stable, with Unguentum Merck showing significant degradation, especially with salicylic acid. Ascorbic or oxalic acid can stabilize anthralin in Unguentum Merck.

    Area of Science:

    • Pharmaceutical Chemistry
    • Dermatological Formulations

    Background:

    • Anthralin is a topical medication used for psoriasis.
    • Understanding anthralin stability in various pharmaceutical bases is crucial for effective treatment.
    • Degradation can impact therapeutic efficacy and safety.

    Purpose of the Study:

    • To evaluate the long-term stability of anthralin in different ointment bases.
    • To identify factors influencing anthralin degradation.
    • To explore methods for stabilizing anthralin formulations.

    Main Methods:

    • Anthralin stability was assessed over one year using a sensitive assay for degradation products.
    • Formulations included white soft paraffin, Lassar's paste, and Unguentum Merck.
    • The effect of varying anthralin concentrations and excipients (salicylic acid, ascorbic acid, oxalic acid) was investigated.

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    Main Results:

    • Anthralin stability was concentration-dependent, with lower concentrations being less stable.
    • Unguentum Merck exhibited significant anthralin degradation, exacerbated by salicylic acid.
    • Ascorbic acid or oxalic acid stabilized anthralin in Unguentum Merck.
    • Salicylic acid enhanced stability in Lassar's paste but not in white soft paraffin.
    • White soft paraffin formulations demonstrated relative stability.

    Conclusions:

    • The choice of pharmaceutical base significantly impacts anthralin stability.
    • Unguentum Merck requires stabilization strategies, such as adding ascorbic or oxalic acid, to maintain anthralin integrity.
    • Formulation optimization is key to ensuring the efficacy and shelf-life of anthralin topical preparations.