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Pathogenic Role of MicroRNA Dysregulation in Podocytopathies

Feng Liu1, Jiefang Chen2, Changqing Luo1

  • 1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Physiology
|July 18, 2022
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in kidney podocyte diseases. Dysregulated miRNAs offer potential as diagnostic biomarkers and therapeutic targets for podocytopathies like FSGS, MCD, MN, DKD, and IgAN.

Area of Science:

  • Molecular Biology
  • Nephrology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) regulate gene expression post-transcriptionally, impacting vital biological processes.
  • Podocytopathies, characterized by podocyte damage, lead to proteinuria and nephrotic syndrome, with unclear pathogenesis and limited therapies.
  • miRNA dysregulation is increasingly implicated in the development and progression of podocytopathies.

Purpose of the Study:

  • To review recent advancements in understanding the role of miRNAs in podocyte dysfunction-related renal disorders.
  • To highlight the potential of miRNAs as diagnostic and prognostic biomarkers for podocytopathies.
  • To explore novel therapeutic strategies targeting miRNAs in kidney diseases.

Main Methods:

  • Literature review of recent research on miRNAs in podocytopathies.
  • Analysis of studies focusing on miRNA dysregulation in specific renal diseases.
  • Examination of research on circulating and urinary miRNAs as biomarkers.

Main Results:

  • miRNA dysregulation plays a critical role in the pathogenesis of podocytopathies.
  • Circulating and urinary miRNAs show promise as non-invasive diagnostic and prognostic biomarkers.
  • Specific miRNAs are implicated in focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranous nephropathy (MN), diabetic kidney disease (DKD), and IgA nephropathy (IgAN).

Conclusions:

  • Dysregulated miRNAs are central to podocytopathy mechanisms.
  • Further research into these miRNAs can uncover novel diagnostic and therapeutic approaches for kidney diseases.
  • miRNAs represent a promising avenue for improving the management of podocytopathies.
Keywords:
IgA nephropathydiabetic kidney diseasefocal segmental glomerulosclerosismembranous nephropathymicroRNAminimal change diseasepodocytopathytherapeutic target

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