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Updated: Sep 4, 2025

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier
Published on: April 5, 2017
Clinical impact of central nervous system-directed therapies on intravascular large B-cell lymphoma: A single
Hiromichi Takahashi1,2, Haruna Nishimaki3, Yoko Nakanishi3
1Department of Medicine Division of Hematology and Rheumatology Nihon University School of Medicine Tokyo Japan.
Abstract:
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of B-cell lymphoma characterized by aggressive disease progression with a high incidence of central nervous system (CNS) involvement. We retrospectively analyzed 16 patients with de novo IVLBCL treated at our hospital between 2004 and 2018 with either standard therapy plus CNS-directed therapy or standard therapy alone. CNS-directed therapy was associated with a significantly better 2-year CNS-free survival (100% vs. 63%, p = 0.0191), despite no significant effects on progression-free or overall survival. Further studies should assess CNS-focused treatment in patients with IVLBCL with or without primary CNS involvement.
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