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Transient left ventricular dysfunction following chimeric antigen receptor T-cell-mediated encephalopathy: A form of
Adam Khorasanchi1, Amir M Ansari1, Wendy Bottinor2
1Department of Internal Medicine Massey Cancer Center, Virginia Commonwealth University Richmond Virginia USA.
Abstract:
Chimeric antigen receptor (CAR) T-cell therapy represents a new strategy in treating lymphoid malignancies, such as relapsed-refractory diffuse large B-cell lymphoma (DLBCL). Several toxicities including cytokine release syndrome (CRS), neurotoxicity, and cardiovascular toxicity have been linked to CAR T-cell therapy. Transient impairment in left ventricular systolic function is described after CAR-T, however, the mechanism remains poorly understood. This paper reports the clinical presentation and outcome of two patients with relapsed-refractory DLBCL who experienced encephalopathy and CRS following CAR T-cell therapy and developed transient left ventricular dysfunction consistent with stress cardiomyopathy.
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