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Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
An optimal control policy in fighting COVID-19 and infectious diseases
1School of Civil Engineering, Cornell University, Ithaca, NY 14853, USA.
Abstract:
When an outbreak starts spreading, policymakers have to make decisions that affect the health of their citizens and the economy. Some might induce harsh measures, such as a lockdown. Following a long, harsh lockdown, the recession forces policymakers to rethink reopening. To provide an effective strategy, here we propose a control strategy model. Our model assesses the trade-off between social performance and limited medical resources by determining individuals' propensities. The proposed strategy also helps decision-makers to find optimal lockdown and exit strategies for each region. Moreover, the financial loss is minimized. We use the public sentiment information during the pandemic to determine the percentage of individuals with high-risk behavior and the percentage of individuals with low-risk behavior. Hence, we propose an online platform using fear-sentiment information to estimate the personal protective equipment (PPE) burn rate overtime for the entire population. In addition, a study of a COVID-19 dataset for Los Angeles County is performed to validate our model and its results. The total social cost reduces by 18% compared with a control strategy where susceptible individuals are assumed to be homogeneous. We also reduce the total social costs by 26% and 22% compared to other strategies that consider the health-care cost or the social performance cost, respectively.
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